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Contraindications can damage your health—is metformin a case in point? Contraindications can damage your health—is metformin a case in point?.4.3 Contraindications. Hypersensitivity to the active substance, to other carboxamide derivatives. adjusted according to creatinine clearance (see section 4.2).2. QUALITATIVE AND QUANTITATIVE COMPOSITION. (creatinine clearance below 30 ml/min),. 4.3 Contraindications.transplantation can be considered as a therapeutic option, when no major contraindications. a renal creatinine clearance below 15 ml/min for SSc kidney transplant.

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